Review summarizes gene variants and inheritance patterns associated with congenital heart disease in heterotaxy syndrome, indicating potential clinical implications.
Key Points
The review reveals that gene variants significantly contribute to congenital heart disease in heterotaxy syndrome, affecting both cardiac and extracardiac functions.
Key findings include that common congenital heart defects linked to heterotaxy syndrome are atrial septal defects and ventricle septal defects.
The review analyzes multiple gene variants, including DNAH11 and ZIC3, along with their potential inheritance patterns such as autosomal dominant and recessive.
Understanding these genetic aspects may enhance clinical approaches to managing congenital heart disease associated with heterotaxy syndrome.