August 14, 2025Nature CommunicationsOpen Access

A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis

View Full Paper

Ask AI

Bookmark

Authors

Discussion

Monoclonal antibody hCitH3-mAb lowers cytokine production and mortality in sepsis models, indicating its potential for immune modulation.

hCitH3-mAb reduces cytokine production and mortality, improving outcomes in sepsis-induced acute lung injury.
In murine models, treatment with hCitH3-mAb resulted in notable reductions in mortality and enhanced phagocytosis.
Assessment using pre-equilibrium digital ELISA identifies a therapeutic window for hCitH3-mAb in treating sepsis.
This monoclonal antibody disrupts the harmful CitH3-driven feedback loop, restoring macrophage function during sepsis.

Ouyang et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark