August 14, 2025Nature CommunicationsOpen Access

COUP-TFII-mediated reprogramming of the vascular endothelium counteracts tumor immune evasion

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Manipulating vascular endothelium improves T cell recruitment in tumors, suggesting new immunotherapy strategies.

Ectopic expression of COUP-TFII enhances T cell recruitment, and reduces tumor growth in mouse models.
COUP-TFII-mediated reprogramming activates venular molecular programs, aiding immune cell trafficking.
Mechanistic studies reveal that COUP-TFII increases vascular adhesion receptors, supporting T cell infiltration.
Findings indicate a crucial role of endothelium in cancer immune evasion, warranting further investigation into therapies.

Zhu et al. (2025) studied this question.

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August 14, 2025Nature CommunicationsOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Manipulating vascular endothelium improves T cell recruitment in tumors, suggesting new immunotherapy strategies.

Ectopic expression of COUP-TFII enhances T cell recruitment, and reduces tumor growth in mouse models.
COUP-TFII-mediated reprogramming activates venular molecular programs, aiding immune cell trafficking.
Mechanistic studies reveal that COUP-TFII increases vascular adhesion receptors, supporting T cell infiltration.
Findings indicate a crucial role of endothelium in cancer immune evasion, warranting further investigation into therapies.

Zhu et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark