To investigate the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with cognitive behavioral therapy (CBT) on neuropsychological status, cognitive function, and sleep microstructure in first-episode depression patients with insomnia. The clinical data of 95 first-episode depression patients with insomnia were retrospectively analyzed. The patients were divided into groups according to the different therapeutic regimens, 45 cases in the control group received conventional treatment, and 50 cases in the research group received rTMS combined with CBT on the basis of conventional treatment. The clinical efficacy, depression level, cognitive function, neuropsychology and sleep quality of the two groups were compared. The overall efficacy rate was higher in the research group compared to the control group (96.00% vs. 80.00%) (p < .05). In addition to conventional pharmacological treatment, the combination of rTMS and CBT may serve as a promising adjunctive intervention for first-episode depression patients with insomnia, demonstrating potential benefits in improving neuropsychological status, cognitive function, and sleep microstructure.
Shi et al. (Thu,) studied this question.