Nickel-catalyzed reaction yields α,β-diamino acid derivatives from imines and α-imino esters, indicating broad functional compatibility.
A nickel-catalyzed reductive cross-coupling reaction of different imines has been developed. This method enables the first reductive cross-coupling between aryl/alkyl imines and α-imino esters, affording α,β-diamino acid derivatives bearing quaternary carbon centers in a single-step process. This imine umpolung strategy exhibits several advantages, such as mild conditions and broad functional group compatibility.
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Zhang et al. (2025) studied this question.
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