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August 16, 2025Frontline GastroenterologyOpen Access

Iatrogenic effect of immune checkpoint inhibitors and targeted therapies on the lower gastrointestinal tract

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Authors

DADua AbuquteishAAAhmad Yousef AlazzamAAAws Khalid Abushanab

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Overview

Review reveals gastrointestinal toxicity from immune checkpoint inhibitors and targeted therapies in cancer treatment, suggesting management strategies for oncologists.

Key Points

  • Colitis and diarrhoea are the most common gastrointestinal side effects of targeted therapies, limiting their use and patient care.
  • Anti-PD-1 and anti-CTLA-4 therapies frequently cause colitis similar to inflammatory bowel disease, suggesting serious adverse effects.
  • Comprehensive literature review assessed lower gastrointestinal toxicities associated with various cancer therapy classes, highlighting treatment management needs.
  • Understanding the gastrointestinal impacts of therapies may enhance patient management and optimize oncological outcomes.

Cite This Study

Abuquteish et al. (2025) studied this question.

synapsesocial.com/papers/68a366a20a429f797332c688https://doi.org/10.1136/flgastro-2025-103094
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune checkpoint inhibitor–related colitis in patients on immunotherapy for cancer2024 · 4 citations
  2. 2Immune checkpoint inhibitor-associated hepatitis and colitis: current understanding and clinical approaches2026
  3. 3Advanced Therapies for the Management of Immune Checkpoint Inhibitor-Induced Colitis2026
  4. 4Review article: Contemporary management of gastrointestinal, pancreatic and hepatic toxicities of immune checkpoint inhibitors2024 · 12 citations
  5. 5Gut microbiome on immune checkpoint inhibitor therapy and consequent immune-related colitis: a review2023 · 25 citations