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August 16, 2025Journal of Complementary and Alternative Medical ResearchOpen Access

Hepatoprotective and Antiplasmodial Effects of Ethanolic Leaf Extracts of Azadirachta indica and Cymbopogon citratus in Plasmodium berghei-Infected Mice

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Authors

UOUzozie Chikere OfoegoPAPrisca Isioma AfamAOAmarachukwu Ndubuisi Ofoego

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Overview

Observational analysis reported improved liver enzyme profiles and reduced parasitemia in mice treated with ethanolic extracts of Azadirachta indica and Cymbopogon citratus, indicating their potential in malaria therapy.

Key Points

  • Marked improvement in liver enzyme profiles was noted in treated groups compared to untreated controls.
  • Parasitemia declined significantly by Days 7 and 14 for all treated groups, highlighting the effectiveness of the extracts.
  • Treatment with the combination of extracts resulted in comparable effects to standard antimalarial drugs.
  • Histological analysis revealed reduced liver damage in extract-treated groups, suggesting protective effects against malaria-related liver injury.

Cite This Study

Ofoego et al. (2025) studied this question.

synapsesocial.com/papers/68a366a80a429f797332cbf9https://doi.org/10.9734/jocamr/2025/v26i8692
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