Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 16, 2025Open Access

DNA Methylation Ageing Atlas Across 17 Human Tissues

View Full Paper
Ask AI
Bookmark
Share

Authors

NENir EynonMJMacsue JacquesKSKirsten Seale

Discussion

Loading...

Member takes

Overview

Meta-analysis identifies conserved and tissue-specific aging signatures in over 15,000 human methylomes, suggesting new therapeutic targets.

Key Points

  • The study reveals comprehensive changes in dna methylation linked to aging across multiple tissues, indicating potential intervention points.
  • Notable findings indicate that certain genes, including PCDHGA1 and HOX, worsen aging signals, suggesting their role in tissue health.
  • Using large-scale meta-analysis of methylomes, researchers identified both conserved and unique aging signatures tied to specific tissues.
  • The findings underline the importance of epigenetic changes in aging, supporting further exploration of biomarkers for therapeutic strategies.

Cite This Study

Eynon et al. (2025) studied this question.

synapsesocial.com/papers/68a366b20a429f797332ce12https://doi.org/10.21203/rs.3.rs-7184037/v1
View Full Paper
Ask AI
Bookmark
Share