Evaluation of hypoallergenic and skin irritation potential of Venusia Ureka cream using human repeat insult patch test

Objectives: This study evaluated the skin irritation and sensitization potential (allergenicity) of Venusia Ureka Cream™ (Dr. Reddy’s Laboratories Ltd., Hyderabad, India), using the Human Repeat Insult Patch Test (HRIPT) technique. Materials and Methods: This single-center, blinded, placebo/vehicle-controlled study evaluated Venusia Ureka Cream™ using HRIPT on adult men and women. Approximately 0.04 g of the cream and 0.04 mL of 0.9% isotonic saline (negative control) were applied occlusively to the back of participants using patch chambers. The study comprised three phases: The induction phase, where nine 24-h patches were applied over 3 weeks and scored using the Draize scale; a rest phase with no patch applications; and a challenge phase, involving one 24-h patch applied to naïve sites, scored at 48, 72, and 96 h using the International Contact Dermatitis Research Group scale. Results: The study included 220 participants, with 217 completing it (142 with normal skin and 75 with sensitive skin, based on the lactic acid sting test). Venusia Ureka Cream™ demonstrated no irritation/hypersensitivity reactions after nine consecutive applications. Both normal and sensitive skin groups showed no adverse reactions. Conclusion: Venusia Ureka Cream™ demonstrated non-irritant properties and was found to be hypoallergenic in the study population. The cream was well-tolerated by participants with both normal and sensitive skin.