Opioid-containing antitussives in Switzerland: a descriptive cross-sectional time-series analysis of pharmacy sales 2013-2022.

Opioid-containing antitussives are used to symptomatically treat a dry, irritative cough but bring a risk of misuse as recreational drugs. Since the update of the Swiss Therapeutic Products Act in 2019, opioid-containing antitussives are regulated more strictly, being available only on prescription and no longer over the counter. This study aimed to describe the sales trends of opioid-containing antitussives in Switzerland between 2011 and 2022 to assess the impact of the regulation change. We descriptively analysed cross-sectional data of opioid sales from wholesalers to pharmacies and self-dispensing physicians as an indicator of community use. An estimated 369 million standard units of opioid-containing antitussives were sold over the whole observation period, of which 59% contained dextromethorphan as the active ingredient. Sales decreased slowly between 2011 and 2019, then dropped substantially in 2020 (-30.4% compared to previous year) and 2021 (-15.2%), then partially recovered in 2022. The sales of codeine-containing antitussives did not recover until the end of the study period (quarter 3 of 2022) and remained 37.3% lower than before the rescheduling (quarter 4 of 2018). It is likely that repeated media attention on cases of misuse of opioid-containing antitussives led to more cautious dispensing in Switzerland leading up to the revision of the Therapeutic Products Act in 2019. The substantial decrease in sales in 2020 and 2021 was likely related to the COVID-19 pandemic rather than the rescheduling of opioid-containing antitussives. Longer data collection will be needed to assess the impact of the regulation change post-pandemic.