This research investigates schiff base complexes, focusing on their antimicrobial effects against bacteria, suggesting potential cancer treatment applications.
In this study, Schiff-base ligand was prepared (LS1) by condensation (methyl 4-amino benzoate) with aldehyde (ortho-vanillin). The prepared schiff-base was identified by FT-IR, UV-Visible, Mass 1H, and 13C-NMR spectroscopy. The electronic spectra of these Azomethine ligand was investigated in terms of acid-base properties, and determination of ionization constants at various pH values (6-12). The complexes were characterized by infrared spectroscopy and measurements of the percentage of copper (II) and the percentage of cobalt (II) using flame atomic absorption spectroscopy, as well as measurements of magnetic susceptibility, molar conductivity, and thermogravimetric analysis. Through the diagnosis and measurements, the geometric shape of the complexes was proposed. Its effectiveness was studied against two types of bacteria and against lung cancer cells.
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Mirdan et al. (2025) studied this question.
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