Correlation study evaluates paraoxonase-1 and GSH levels in cancer patients, indicating impaired antioxidant defense linked to gynecological cancer hazards.
Paraoxonase (PON 1) is an important antioxidant enzyme that degrades lipid peroxidation and acts as a biomarker for carcinogenicity. The aim of this study was to compare the blood levels of paraoxonase-1 activity and glutathion GSH in Iraqi female cancer patients to those in healthy controls. Serum paraoxonase-1 activity and GSH levels were measured in patients with ovarian cancer (n = 40), uterine cancer (n = 40), and controls. Results: Patients exhibited significantly decreased serum paraoxonase and GSH levels compared to controls (p < 0.001).Conclusion: Low blood PON 1 activity may lead to an impaired antioxidant defense system, which is significant in carcinogenesis in people with gynecological malignancies.
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Zaidan et al. (2025) studied this question.
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