In this study, the stability of azithromycin, which is considered one of the most important macrolide antibiotics, was identified; which means that it is a broad-spectrum antibiotic effective against both Gram-positive and Gram-negative microorganisms. The stability of the drug azithromycin was studied for five different companies: (Jamjoem Pharma, LDP Laboratories, Torlan S.A. Ajanta Pharma Ltd, GET and Brawn), and the decomposition of the drug was studied at different temperatures (40, 50, 60 and 70) Celsius; and the Shelf Leaf value was calculated. The reaction rate constant for the drug was determined using the Arrhenius equation and the first-order reaction equation for each drug manufacturing company ;It was found that LDP is considered the best among the five companies for the drug azithromycin in resisting temperature during storage and can be stored for a longer period than the drug belonging to other companies; while ZAHA showed the reduction. The lowest resistance to change at high temperature and greater decomposition of the drug, in addition to its lack of resistance to heat and its stability when stored for a certain period.
Ali et al. (Fri,) studied this question.
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