Unraveling the S−S∙∙∙π Interactions in Furan-Disulfide Heterodimers: Insights from Microwave Spectroscopy and Ab initio Computations

Q: What type of study is this?

This is a In Vitro Study study.

Fang Shen; Liuting Wang; Renhua Chen; Wenqin Li; Yuting Li; Yan Feng; Tao Lü; Walther Camináti; Alberto Lesarri; Gang Feng

doi:10.1039/d5cp02557e

January 1, 2025Physical Chemistry Chemical Physics

Unraveling the S−S∙∙∙π Interactions in Furan-Disulfide Heterodimers: Insights from Microwave Spectroscopy and Ab initio Computations

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Key Points

The research uncovers critical non-covalent interactions in furan-disulfide heterodimers, impacting protein stability and functionality.
Key evidence shows significant S−S interactions with aromatic rings, influencing protein-ligand interactions.
Observational analysis using microwave spectroscopy and ab initio computations provides detailed interaction insights.
Findings underscore the importance of understanding these interactions for better therapeutic designs in biochemistry.

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Implication

Microwave spectroscopy reveals non-covalent interactions in furan-disulfide heterodimers, highlighting their structural importance.

Abstract

The non-covalent interactions between sulfur atoms and aromatic rings are critically important in maintaining the structural integrity, stability, and functionality of proteins and protein-ligand complexes. Nonetheless, the fundamental characteristics of...

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Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68a36c1a0a429f797332f5e3 https://doi.org/10.1039/d5cp02557e

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Unraveling the S−S∙∙∙π Interactions in Furan-Disulfide Heterodimers: Insights from Microwave Spectroscopy and Ab initio Computations

Key Points

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Implication

Abstract

Discussion

Cite This Study

Unraveling the S−S∙∙∙π Interactions in Furan-Disulfide Heterodimers: Insights from Microwave Spectroscopy and Ab initio Computations

Key Points

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Implication

Abstract

Discussion

Cite This Study

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