A Key Role of Dietary Nonallergic Factors in the Pathogenesis of Asthma and Rhinitis

An increasing number of scholars are paying attention to “diet and asthma,” with a focus on overall calorie metabolism and related factors, such as obesity and corresponding interventions, dietary restrictions, and calorie consumption (exercise). We proposed this concept of dietary non-allergic factors (DNAF) in 2005. We now discuss the comprehensive and in-depth relationship between DNAF and asthma through macro (epidemiology), meso (clinical randomized controlled trials), and micro (pathophysiological changes) perspectives. Through analysis of the gutlung axis, we believe that mediators of mast cells may directly originate from undigested fats and proteins in the intestine. Inflammatory cell infiltration of the airways is also closely related to increased intestinal permeability.