Guanidinium Linked Morpholino-siRNA Chimera: Synthesis, Biophysical Properties and in vitro Activity

Q: What type of study is this?

This is a In Vitro Study study.

Shalini Gupta; Atanu Ghosh; Subhamoy Pratihar; Mandira Mukherjee; Jayanta Kundu; Surajit Sinha

doi:10.1039/d5cc03543k

January 1, 2025Chemical Communications

Guanidinium Linked Morpholino-siRNA Chimera: Synthesis, Biophysical Properties and in vitro Activity

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Key Points

Enhanced RNA interference activity was demonstrated with guanidinium morpholino RNA in cell models, suggesting promising applications.
The study shows that guanidinium morpholino RNA displays improved cell permeability and nuclease resistance, enhancing its functionality.
Self-penetrating guanidinium morpholino RNA chimeras were synthesized with effective in vitro activities, demonstrating their unique biophysical properties.
These findings imply that guanidinium morpholino RNA could lead to advanced therapeutic strategies for targeting RNA molecules.

Implication

In vitro analysis shows enhanced RNA interference activity and cell permeability of guanidinium morpholino RNA, indicating potential therapeutic uses.

Abstract

This study introduces guanidinium morpholino RNA (GMO-RNA), an RNA analogue with enhanced cell permeability, nuclease resistance and RNA interference activity. Self-penetrating GMO-RNA chimeras leverage guanidinium-mediated endocytic uptake across multiple cell...

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Cite This Study

Gupta et al. (2025) studied this question.

synapsesocial.com/papers/68a36dd20a429f7973330a09 https://doi.org/10.1039/d5cc03543k

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Guanidinium Linked Morpholino-siRNA Chimera: Synthesis, Biophysical Properties and in vitro Activity

Key Points

Implication

Abstract

Discussion

Cite This Study

Guanidinium Linked Morpholino-siRNA Chimera: Synthesis, Biophysical Properties and in vitro Activity

Key Points

Implication

Abstract

Discussion

Cite This Study

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