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This is a Observational study (also classified as: In Vitro Study).

August 17, 2025

Supplemental Figure S3 from Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5

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Collagen XVII promotes tumor growth in pancreatic ductal adenocarcinoma, enhancing proliferation and survival.
Key evidence indicates regulation of PIK3R5 in the tumor microenvironment by collagen XVII.
Assessment through immunohistochemical and histologic analysis elucidated tumor characteristics in COLXVII-deficient cells.
Findings support further exploration of collagen roles in PDAC, highlighting potential therapeutic approaches.

Histologic analysis shows collagen's influence on tumor growth in PDAC, suggesting PIK3R5's role in this process.

Immunohistochemical and histologic analysis of collagen and fibroblast content of tumors formed by COLXVII-deficient PDAC cells

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Hank et al. (2025) studied this question.

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Histologic analysis shows collagen's influence on tumor growth in PDAC, suggesting PIK3R5's role in this process.

Immunohistochemical and histologic analysis of collagen and fibroblast content of tumors formed by COLXVII-deficient PDAC cells