Immunohistochemical analysis reveals that ionizing radiation alters salivary gland cell behavior, suggesting cancer risk.
Background: Radiation therapy with ionizing radiation is associated with an increased risk of salivary gland cancer and xerostomia due to an abnormally high expression of the regulatory protein calponin. PCNA is a cofactor for DNA polymerase-delta and is involved in cell proliferation.Methods: This study evaluated the anti-calponin and anti-PCNA immunohistochemical reactivity in the parotid salivary glands of mice after frequent exposure to dental X-ray.Results: The results showed that exposure to radiation causes marked differences in PCNA reactivity. Radiation therapy has a significant impact on salivary glands, particularly on myoepithelial cells.Conclusion: The exposure to radiation can cause Dental X-ray exposure increases the risk of developing cancer and other health problems due to damage to DNA and inflammatory destruction and further research is needed to mitigate these effects and improve patient outcomes.
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Muhammad et al. (2023) studied this question.
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