Observational analysis reveals differential expression of eicosanoid pathways in patients with chronic rhinosinusitis, suggesting targeted dupilumab therapy may aid in severity assessment.
Key Points An untargeted transcriptomic analysis provided exploratory insight into key genes and pathways that can be used to help identify patients at risk for surgically refractory chronic rhinosinusitis with nasal polyps (CRSwNP). The Charcot–Leyden crystal gene, periostin and osteopontin‐associated pathways, eicosanoid synthesis pathway, and prostaglandin/leukotriene metabolism pathway, among others, are associated with dupilumab prescription for surgically refractory chronic rhinosinusitis and may support early stratification of disease severity in CRSwNP patients.
No takes yet. Share an insight, caveat, or question.
Dorismond et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: