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This is a Animal Study study (also classified as: In Vitro Study).

August 21, 2025Open Access

A Toolkit for In Vivo Mapping and Modulating Neurotransmission at Single-Cell Resolution

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Genetic tools enhance visualization and manipulation of neurotransmitters in C. elegans, indicating co-transmission in neurons.

Over 10% of neurons in C. elegans show co-transmission of neurotransmitters.
The toolkit utilizes genetically engineered vesicular transporters for glutamate, GABA, and acetylcholine.
This approach includes conditional knockout strains for targeted disruption of neurotransmitter synthesis.
Findings suggest that neurotransmitter identity can be monitored and manipulated to understand synaptic communication.

Cuentas-Condori et al. (2025) studied this question.

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August 21, 2025Open Access

View Full Paper

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Authors

Genetic tools enhance visualization and manipulation of neurotransmitters in C. elegans, indicating co-transmission in neurons.

Over 10% of neurons in C. elegans show co-transmission of neurotransmitters.
The toolkit utilizes genetically engineered vesicular transporters for glutamate, GABA, and acetylcholine.
This approach includes conditional knockout strains for targeted disruption of neurotransmitter synthesis.
Findings suggest that neurotransmitter identity can be monitored and manipulated to understand synaptic communication.

Cuentas-Condori et al. (2025) studied this question.

View Full Paper

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