Modulation of senescence-related changes in the small and large intestine of experimental animals with induced aging

To identify patterns of histological changes in the small and large intestines of white mice, as well as to evaluate the corrective potential of senolytic agents in these conditions, the authors conducted a study using outbred white mice selected based on a case-control design. A selective p53 activator – FOXO4DRI – was used. On day 14 following doxorubicin administration, the results obtained allowed for key conclusions regarding the presence of distinct sex-based differences in response to equivalent doses of doxorubicin. The senolytic agent FOXO4DRI demonstrated a pronounced pro-apoptotic effect, particularly in labile cell populations. Additionally, the intensity of the response to the drug showed a dose-dependent pattern.