Aromatic diamines: isolation, determination in migration solutions of polymeric materials, biomaterials, textile products and cosmetics

Based on modern international environmental and food safety requirements, the issue of determining the residual content of aromatic diamines in food products, cosmetics and other polymer and biomaterials is extremely relevant. Aim. Review of modern approaches to isolation and determination of primary aromatic diamines in migration solutions as a potential source of contamination of consumer goods. Materials and Methods. Generalized publications devoted to the isolation and determination of aromatic diamines in migration solutions of polymeric materials, biomaterials and cosmetics. A technique for determining the mass concentration of aromatic diamines in migration solutions by the HPLC method (Waters, USA) in the reversed-phase version with photometric detection has been developed. The research was carried out on a Waters 600 liquid chromatography with a Waters 996 diode-matrix photometric detector (Waters Nova Pak C18 column, 3.5 μm (150x2.1 mm). Identification of aromatic diamines was carried out by their residence time (min.) in the column. Results. We obtained the dynamics of the levels of aromatic diamines in the packaging film for packing mayonnaise immediately after its production and during 14 days: on the 3rd day, the maximum number of amines migrating into the model environment was registered; no aromatic diamines were detected after 14 days (<2.0 μg/l). Conclusion. The analysis of literary sources and the results of our own research confirm the relevance of analytical studies of aromatic diamines as highly toxic compounds, which requires the improvement of existing methods of control of packaging material for the content of aromatic diamines and degradation products of azo dyes.