Role of Cognitive Function in Functional Outcome in Psychotic and Affective Inpatients

Abstract Background The functional outcome of inpatient psychiatry is a central clinical concern. It is well-established that good neurocognition is an important factor in achieving a favourable functional outcome. Aims Sachs et al. Schiz Res Cogn 2022, 29, 100259). According to the ICD-10 research criteria, 83 patients received an F2 diagnosis (schizophrenia, schizoaffective and delusional disorders), 61 patients met the criteria for bipolar disorder or mania (F30/F31) and 90 for depression (F32/F33). All patients received state-of-the-art pharmacotherapy and cognitive remediation using the COGPACK® software package version 6.06. Functioning was assessed using the Global Assessment of Function (GAF). Results SCIP scores at baseline demonstrated a significant correlation with SCIP scores at time point two (r=.74, p.001). Furthermore, a strong correlation was identified between the SCIP at baseline and patients' functional level (r=.32, p=.01). It was observed that higher baseline SCIP scores were associated with higher GAF scores (r=.33, p=.01). A higher GAF score at baseline is associated with a higher SCIP score at time point two (r=.26, p=.039). Furthermore, a higher SCIP score at time point two is associated with a higher GAF score at time point two (r=.42, p.001). Discussion & Conclusions During their period of hospitalisation, patients who were acutely admitted to the hospital demonstrated improvements in both function and neurocognition, irrespective of their diagnostic classification. The functionality of these patients, as measured by the Global Assessment of Functioning (GAF), exhibited a significant correlation with their cognitive ability, as evaluated by the SCIP-G.