Ultrasound-Responsive Azide Nano-prodrugs Enable Spatiotemporal Activation of TLR7/8 Agonists for Tumor Therapy

Chuwen Luo; Chaoying Kong; Yuxiao Zhang; Yajun Xu; Zhaohui Tang

doi:10.1039/d5bm00755k

January 1, 2025Biomaterials ScienceOpen Access

Ultrasound-Responsive Azide Nano-prodrugs Enable Spatiotemporal Activation of TLR7/8 Agonists for Tumor Therapy

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Key Points

Ultrasound-responsive azide prodrugs enable targeted activation of therapies, decreasing systemic immunotoxicity.
In vitro tests show significant reductions in off-target effects using azide-modified TLR7/8 agonists.
Utilizing ultrasound, the modified IMDQ drugs selectively activate at tumor sites, improving effectiveness.
The findings advocate for safer tumor therapies based on ultrasound activation and targeted drug delivery.

Implication

Ultrasound-responsive azide nano-prodrugs enhance TLR7/8 agonist effects in tumors, suggesting reduced immunotoxicity.

Abstract

Systemic immunotoxicity caused by off-target activation is still a critical obstacle to clinical translation of imidazoquinoline (IMDQ) drugs, a kind of TLR7/8 agonists. Here, we present an ultrasound-responsive, azide-modified IMDQ...

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Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/68af454cad7bf08b1ead329d https://doi.org/10.1039/d5bm00755k

View Full Paper

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Ultrasound-Responsive Azide Nano-prodrugs Enable Spatiotemporal Activation of TLR7/8 Agonists for Tumor Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Ultrasound-Responsive Azide Nano-prodrugs Enable Spatiotemporal Activation of TLR7/8 Agonists for Tumor Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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