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August 19, 2025Journal of Experimental BiologyOpen Access

Increases in cortisol production facilitate the transition to exogenous feeding by larval zebrafish

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Authors

BCBrett M. CulbertEMEmma MossingtonJAJ. L. Anthony

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Overview

Pharmacological suppression of cortisol reduced feeding rates and enzyme transcripts in larval zebrafish, indicating its regulatory role.

Key Points

  • Cortisol influences mouth feeding transition in zebrafish, revealing its crucial developmental role.
  • Inhibition of cortisol production lowered digestive enzyme transcripts and feeding rates during early development.
  • Pharmacological approach involved administering metyrapone to suppress cortisol from 3 to 5 days post-fertilization.
  • Findings suggest a conserved regulatory mechanism for feeding transitions across vertebrate species.

Cite This Study

Culbert et al. (2025) studied this question.

synapsesocial.com/papers/68af4551ad7bf08b1ead36dahttps://doi.org/10.1242/jeb.250921
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