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January 1, 2025Chemical Science22 citationsOpen Access

Kinase signaling cascades: An updated mechanistic landscape

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RNRuth NussinovCRClil RegevHJHyunbum Jang

Key Points

  • Kinase signaling cascades play a crucial role in regulating cell proliferation, responding effectively to external stimuli.
  • Key pathways include the Ras network, MAPK, and PI3K/AKT/mTOR, which are pivotal in cell signaling mechanisms.
  • This analysis highlights the mechanisms involved in signal transduction, enhancing understanding of cellular functions.
  • Insights into these cascades may lead to advancements in therapies targeting cell proliferation and growth.

Abstract

Here we shed physico-chemical light on major kinase signal transduction cascades in cell proliferation in the Ras network, MAPK and PI3K/AKT/mTOR. The cascades respond to external stimulus. The kinases are...

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Cite This Study

Nussinov et al. (2025) studied this question.

synapsesocial.com/papers/68af474ead7bf08b1ead39f3https://doi.org/10.1039/d5sc04657b
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