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August 19, 2025

N-Acetylcysteine for Treatment of Anemia in Children with Kidney Failure: A Prospective Study

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Authors

HMHeba El‐Sayed MostafaZagazig UniversityFMFatema A Abdel MaksoudCairo UniversityASAhmed Reda SayedBeni-Suef University

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Implication

Prospective study shows N-acetylcysteine improves anemia and cardiac function in children with kidney failure undergoing hemodialysis, indicating potential benefits for oxidative stress.

Key Points

  • N-acetylcysteine significantly improved hemoglobin levels in children with kidney failure after 3 months of treatment.
  • A notable increase in total antioxidant capacity and a decrease in total oxidative stress were observed with NAC administration.
  • This prospective study involved 48 children undergoing maintenance hemodialysis, measuring various hematological and cardiac indices.
  • The findings suggest that NAC may protect against cardiovascular disorders associated with chronic kidney disease in this population.

Cite This Study

Mostafa et al. (2025) studied this question.

synapsesocial.com/papers/68af475aad7bf08b1ead4177https://doi.org/10.21203/rs.3.rs-7320259/v1
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Also Consider

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  1. 1Cardiac Remodeling in Chronic Kidney Disease2020 · 152 citations
  2. 2Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease2020 · 361 citations
  3. 3Effect of N-Acetylcysteine on Total Oxidant Status in Children With β-Thalassemia Major2020 · 4 citations
  4. 4Impact of Hemodialysis Therapy on Anemia of Chronic Kidney Disease: The Potential Mechanisms2011 · 53 citations
  5. 5Burden of Anemia in Chronic Kidney Disease: Beyond Erythropoietin2020 · 223 citations