T Cell Receptor Repertoires Are Skewed in South African Patients With Multisystem Inflammatory Syndrome in Children

Multisystem inflammatory syndrome in children (MIS-C) is a severe response to SARS-CoV-2 that affects a small proportion of children. Overexpression of a nonspecific T cell receptor beta variable 11-2 in multiple populations has led to the hypothesis of a superantigen response underlying MIS-C. Here, we describe T cell receptor beta variable 11-2 expansion in South African children with MIS-C, supporting a common pathogenesis of MIS-C regardless of location.