An evaluation of the clinical effectiveness of autologous bone marrow cells as a supplement to traditional therapy for wound healing in canine

A wound is defined as a breach in the integrity of tissue. Wound healing is an essential requirement of all surgical manipulation, and has the focus of various treatment strategies aimed at enhancing this process. The present retrospective study was carried out with an objective to evaluate the comparative efficacy of local transplantation of autologous whole bone marrow (WBM) in conjunction with conventional therapy versus conventional therapy alone in promoting wound healing in dogs. A total of 14 clinical cases of dogs were randomly selected, irrespective of breed, age, sex, and reproductive status, and divided into two equal groups – Group A and Group B. The dogs in Group A received only conventional wound management, while Group B dogs were treated with local transplantation of autologous WBM along with conventional therapy. The rate of wound healing was accessed on the basis of clinical parameters including appetite, level of activity, visual analogue score (evaluating pain, swelling, and exudation), total healing (on days 0, 3, 7, and 10), and the total number of days required for complete healing/ suture removal. The statistical analysis of the collected data was performed by software SPSS 17, using two-way analysis of variance (ANNOVA). On the basis of clinical findings, it was concluded that addition of local transplant of autologous WBM to conventional wound management therapy significantly increased the quality and rate of wound healing in dogs compared to conventional therapy alone.