Fibrolamellar Carcinoma, A Rare Tumor with Distinctive Features: A Case Report

Fibrolamellar carcinoma (FLC) is a rare and aggressive tumor. FLC typically occurs in children and young adults and is known to be associated with a unique gene mutation. Unlike conventional hepatocellular carcinoma, it presents with unique clinical and histologic features and poses significant diagnostic and therapeutic challenges. Its pathogenesis remains poorly understood. Currently, both histopathologic and biomolecular studies contribute to its characterization. Herein, we report the case of a 43-year-old patient with diabetes mellitus and two previous hepatic resections, who presented with a newly identified lesion in segment IVa of the liver. Imaging, including MRI and PET-CT, revealed a metabolically active mass in close contact with the diaphragm. The patient underwent exploratory laparoscopy and subsequent surgical resection. Histopathologic and immunohistochemical studies (positive for CK7, CD68, and AE1/AE3) supported the diagnosis of fibrolamellar carcinoma.