Water-soluble photolabile ruthenium(II) complex with a terpyridyl-dicarboxylate ligand: photocytotoxicity triggered by structural strain

Pritha Chatterjee; Madhu Verma; Avinash Kumar Sonkar; Abhijit Saha; Ramranjan Mishra; Sri Sivakumar; Ashis K. Patra

doi:10.1039/d5qi01110h

January 1, 2025Inorganic Chemistry Frontiers

Water-soluble photolabile ruthenium(II) complex with a terpyridyl-dicarboxylate ligand: photocytotoxicity triggered by structural strain

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Key Points

Photocytotoxicity is triggered by structural strain in the complex, enhancing its therapeutic profile.
Incorporating the terpyridyl-dicarboxylate ligand facilitates effective photorelease under light exposure.
The excited state structural distortions enable the release of labile groups, leading to improved cytotoxic effects.
This innovative approach may inspire further advancements in photopharmacology and targeted therapies.

Implication

The newly designed photolabile ruthenium(II) complex shows photocytotoxicity with structural strain, highlighting its potential applications.

Abstract

Structural distortions in the excited state can facilitate the photorelease of kinetically labile groups in Ru(II) polypyridyl complexes. Leveraging on this, here we report, for the first time, the design...

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Cite This Study

Chatterjee et al. (2025) studied this question.

synapsesocial.com/papers/68af4959ad7bf08b1ead5304 https://doi.org/10.1039/d5qi01110h

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Water-soluble photolabile ruthenium(II) complex with a terpyridyl-dicarboxylate ligand: photocytotoxicity triggered by structural strain

Key Points

Implication

Abstract

Discussion

Cite This Study

Water-soluble photolabile ruthenium(II) complex with a terpyridyl-dicarboxylate ligand: photocytotoxicity triggered by structural strain

Key Points

Implication

Abstract

Discussion

Cite This Study

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