Observational analysis revealed pentagalloyl glucose reduces ciprofloxacin resistance in Staphylococcus aureus, suggesting it may enhance antibiotic efficacy.
Pentagalloyl glucose (PGG) was identified as a potential inhibitor of NorA, NorB, NorC and SdrM efflux pumps in S. aureus . PGG was further validated as a ciprofloxacin-adjuvant which declined the growth of ciprofloxacin-resistant S. aureus strain.
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Harikumar et al. (2025) studied this question.
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