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August 15, 2025ImmunoOpen Access

Immunophenotyping and Functional Characterization of NK Cells in SARS-CoV-2 Infection

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Authors

СПС. В. ПетровMBMartina BozhkovaMIMariya Ivanovska

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Overview

This analysis reveals alterations in NK cells during SARS-CoV-2 infection, suggesting ongoing immune dysregulation.

Key Points

  • NK cells show changes in activation markers during SARS-CoV-2 infection, hinting at immune adaptation.
  • Significant changes in NK cell subsets were observed, with increased NKG2A and NKG2D marker expression over time.
  • Peripheral blood samples collected between days 3-5 and 30 post-symptom onset were key for understanding NK cell dynamics.
  • These findings imply that NK cell exhaustion may occur during COVID-19, along with a retention of antiviral capabilities.

Cite This Study

Петров et al. (2025) studied this question.

synapsesocial.com/papers/68af4965ad7bf08b1ead5b91https://doi.org/10.3390/immuno5030035
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