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August 20, 2025JOR SpineOpen Access

Wharton's Jelly Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System

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Authors

VTVeronica TilottaGVGianluca VadalàGGGiuseppina Di Giacomo

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Overview

Laboratory analysis shows that Wharton's Jelly MSC-derived extracellular vesicles improve nucleus pulposus cell survival, suggesting a novel treatment for intervertebral disc degeneration.

Key Points

  • WJ-MSC-derived extracellular vesicles promoted hNPC proliferation, counteracting inflammatory effects effectively.
  • At 10 μg/mL, the EVs reduced nitrite production and cell death in hNPCs exposed to IL-1β.
  • Analysis showed that GAG content increased dose-dependently along with positive modulation of anabolic and catabolic genes.
  • These findings indicate potential for WJ-evs as a cell-free therapy for intervertebral disc degeneration.

Cite This Study

Tilotta et al. (2025) studied this question.

synapsesocial.com/papers/68af4cd3ad7bf08b1ead5f29https://doi.org/10.1002/jsp2.70106
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