Unusual occurrence of solid tumors with hematological malignancies

The co-occurrence of multiple primary tumors in one person is not uncommon, with a reported prevalence of multiple primary malignancy (MPM) ranging between 0.73% and 11.7%, depending on the definition. But the combination of solid organ tumors with hematological malignancy is rare. Herein, we report five cases, one with therapy-related, one metachronous, and three synchronous hematological and non-hematological malignancies. The management of MPM is challenging as there is no therapeutic guideline for treating these rare presentations.