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August 21, 2025Frontiers in EndocrinologyOpen Access

McCune–Albright syndrome with multiple hyperfunctional endocrinopathies: diagnosis, treatment, and long-term follow-up: a case report

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Authors

MZMariam J. ZainabLKLabibah L. KhamiesJBJ.F. Baladi

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Overview

Case report details effective treatment for multiple endocrinopathies in a child with McCune-Albright syndrome, suggesting long-term strategies for care.

Key Points

  • The patient's complex presentation included hyperfunctioning endocrinopathies and fibrous dysplasia, necessitating tailored treatment.
  • At 8 years old, the girl exhibited multiple endocrinopathies originating from GNAS gene mutations, such as growth hormone excess.
  • Management involved carbimazole, letrozole, lanreotide, and zoledronic acid to address complex hormonal interactions.
  • This report underscores the need for comprehensive long-term follow-up in pediatric cases of McCune-Albright syndrome.

Cite This Study

Zainab et al. (2025) studied this question.

synapsesocial.com/papers/68af50a7ad7bf08b1ead8fddhttps://doi.org/10.3389/fendo.2025.1632257
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