A cost effective protocol for methylome and genome screen using ddRAD and high-throughput sequencing v1

The protocol describes the preparation of constructing high-throughput sequencing libraries that would allow scanning both the methylome and the genome of a targeted organism. The protocol is mainly desinged in relation to breeding activities where one needs to screen a large number of animals. The protocol is a compilation of library construction demonstrated in the following: Peterson et al 2012 Palaiokostas et al 2015 Franchini et al 2017 Marconi et al 2019