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Cytogenetic profiling reveals genomic stability in chondrocytes and chondroprogenitors, suggesting safer transplantation options.
Purpose Cartilage-derived chondroprogenitors, with inherent chondrogenic capacity and low hypertrophic potential, represent a promising avenue for cartilage regeneration. For clinical translation, assessment of cellular genomic stability is a quality control mandate. Since culturing cells to higher passage numbers for achieving the cell requirement is indispensable, it is necessary to evaluate the possibility of culture-driven mutations before transplantation. Being a relatively newly discovered cell subset, the information on the genetic profile of these cartilage-resident cells is notably limited.
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Karunya.B et al. (2025) studied this question.
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