Identification and structural insights into RNA motifs targeted by a CAG repeat DNA-binding small molecule

Qingwen Chen; Akira Fujiwara; Kazuhiko Nakatani; Gota Kawai; Asako Murata

doi:10.1039/d5sc05255f

January 1, 2025Chemical ScienceOpen Access

Identification and structural insights into RNA motifs targeted by a CAG repeat DNA-binding small molecule

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Key Points

Unique binding mode of rna motifs revealed through various analytical techniques, providing insights into molecular interactions.
Key evidence includes structural characterization using nmr, which highlighted interactions between rna motifs and the small molecule.
In vitro selection method identified rna motifs, leading to detailed studies using methods like spr and ms for validation.
Findings may enable new approaches in targeting rna structures with small molecules, advancing therapeutic strategies.

Implication

Observational analysis uncovered unique rna motifs binding to a cag repeat small molecule, indicating novel interactions.

Abstract

Novel RNA motifs binding to a small molecule NA were identified via in vitro selection. A conserved internal loop was characterized, and its interaction with NA was investigated by NMR, SPR, UV melting, and MS, revealing a unique binding mode.

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af521fad7bf08b1ead9ed0 https://doi.org/10.1039/d5sc05255f

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Identification and structural insights into RNA motifs targeted by a CAG repeat DNA-binding small molecule

Key Points

Implication

Abstract

Discussion

Cite This Study

Identification and structural insights into RNA motifs targeted by a CAG repeat DNA-binding small molecule

Key Points

Implication

Abstract

Discussion

Cite This Study

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