Mixed-methods analysis shows that neuropsychological intervention and ACT significantly reduce pain catastrophizing in MS patients.
Purpose: This study aimed to examine the effectiveness of two therapeutic interventions based on a neuropsychological approach and Acceptance and Commitment Therapy (ACT) in reducing pain catastrophizing in MS patients. Methods and Materials: The research employed a mixed-methods (qualitative-quantitative) design, with the study population consisting of MS patients attending healthcare centers in Isfahan in 2023-2024. From this population, 45 individuals were randomly selected and assigned to three equal groups: experimental group 1 (15 participants), experimental group 2 (15 participants), and a control group (15 participants). The first group received treatment based on the neuropsychological approach, while the second group underwent ACT. Data collection tools included the Pain Catastrophizing Questionnaire and a demographic questionnaire, and data were analyzed using univariate analysis of covariance. Findings: The results indicated that both therapeutic interventions led to a significant reduction in pain catastrophizing in MS patients. The F-values for the magnification and rumination variables in the experimental groups were significantly higher than in the control group (p < 0.05). Conclusion: These findings suggest that both interventions can effectively reduce pain catastrophizing and may be considered effective treatment approaches.
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Nik et al. (2025) studied this question.