Composite Nano Copper Carrier Combined Cuproptosis and Photodynamic Therapy for Spatiotemporal Synergistic Anti-Tumor

Yong‐Guo Hu; Fang Zhang; Lili Chen; Xiaobin Xu; Pei‐Jie Zhang; Yong Li; Jin‐Xuan Fan; Jian Zou; Yuan‐Di Zhao

doi:10.1039/d5bm00954e

January 1, 2025Biomaterials Science

Composite Nano Copper Carrier Combined Cuproptosis and Photodynamic Therapy for Spatiotemporal Synergistic Anti-Tumor

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Key Points

This approach enhances anti-tumor efficacy through a dual mechanism involving cuproptosis and photodynamic therapy, offering a novel strategy for cancer treatment.
Crucially, it achieves tumor-specific copper delivery, minimizing systemic toxicity while effectively triggering cancer cell death.
The nanoplatform design integrates two therapeutic modalities, cuproptosis and photodynamic therapy, for a spatiotemporal synergistic effect on cancer cells.
This strategy may enable localized treatment options, highlighting significant advancements in targeted cancer therapies with reduced side effects.

Implication

Innovative nanoplatform improves tumor-targeted copper delivery, suggesting enhanced anti-tumor efficacy and reduced toxicity.

Abstract

Cuproptosis is a copper-dependent programmed cell death triggered by mitochondrial dysfunction, offers significant anti-tumor potential but requires tumor-specific copper delivery to avoid systemic toxicity. Here, we developed a synergistic nanoplatform...

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Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68af53ffad7bf08b1eada84e https://doi.org/10.1039/d5bm00954e

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Composite Nano Copper Carrier Combined Cuproptosis and Photodynamic Therapy for Spatiotemporal Synergistic Anti-Tumor

Key Points

Implication

Abstract

Discussion

Cite This Study

Composite Nano Copper Carrier Combined Cuproptosis and Photodynamic Therapy for Spatiotemporal Synergistic Anti-Tumor

Key Points

Implication

Abstract

Discussion

Cite This Study

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