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August 22, 2025Open Access

The claudin-like molecule CLC-3 regulates neuromuscular function in Caenorhabditis elegans by modulating cholinergic signalling

Aishwarya Ahuja Anjay Rastogi Haowen Liu Abhilash Sahu Hrishikesh Kumar Jagannath Jayaraj Zhitao Hu Kavita Babu

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Key Points

CLC-3 influences cholinergic signalling, affecting motor output and body movement in C. elegans, demonstrating its functional importance.
Increased body-bend amplitude and elevated postsynaptic currents were observed in clc-3 mutants, revealing its regulatory role.
A transcriptional reporter screen identified neuronal expression of claudin-like genes, emphasizing the significance of cell adhesion molecules.
CLC-3 localizes to presynaptic membranes in cholinergic neurons, interacting with NAB-1 and influencing synaptic organization.

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Implication

Functional analysis shows CLC-3 regulates cholinergic signalling in C. elegans, suggesting broader roles for claudins in neuronal expression.

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Cite This Study

Ahuja et al. (2025) studied this question.

synapsesocial.com/papers/68af540fad7bf08b1eadb13e https://doi.org/10.1101/2025.08.18.670992

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The claudin-like molecule CLC-3 regulates cholinergic neurotransmission in <i>Caenorhabditis elegans</i>Original Research · 2026
2Loss of neuropeptidergic regulation of cholinergic transmission induces CaV1-mediated homeostatic compensation in muscle cells2024
3Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous systemOriginal Research · 2009 · 19 citations
4Increased tissue tension caused by depletion of CLDN3 in the non-neural ectoderm causes neural fold fusion defects in chick embryos2025
5Identification of an N‐terminal amino acid of the CLC‐3 chloride channel critical in phosphorylation‐dependent activation of a CaMKII‐activated chloride currentpreclinical · 2004 · 68 citations

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