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August 22, 2025Open Access

Inhibitory NK receptors regulate the γδ T cell response to malaria

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Inhibitory NK receptors modulate γδ T cell responses to malaria, balancing activation and inhibition for effective immune response.
Significant differences in NK receptor expression on γδ T cell subsets were identified, particularly in Ugandan children exposed to malaria.
Spectral flow cytometry analyzed PBMCs, revealing divergent control mechanisms in Vγ9 + Vδ2 + T cells compared to other subsets.
These findings suggest potential interventions to enhance immune responses in high malaria burden populations, indicating a novel immunological pathway.

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This analysis reveals how NK receptors regulate γδ T cell responses to malaria in Ugandan children, indicating immune adaptation.

Olive et al. (2025) studied this question.

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