Revisiting the biophysical aspects of extracellular-matrix–mimicking hydrogels: what cells see vs. what cells feel

J. Sui; Sarah Pragnère; Nicholas A. Kurniawan

doi:10.1039/d5bm00210a

January 1, 2025Biomaterials ScienceOpen Access

Revisiting the biophysical aspects of extracellular-matrix–mimicking hydrogels: what cells see vs. what cells feel

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Key Points

Cell behavior significantly influences tissue function, providing insights into how extracellular matrix surrogates affect these dynamics.
Development of ECM surrogates helps researchers understand complex cell–ECM interactions and their implications for tissue engineering.
This analysis of hydrogels offers a fresh perspective on the biophysical characteristics essential for mimicking the extracellular matrix.
Improved understanding of cell behavior in relation to ECM surrogates may enhance biomedical applications in tissue regeneration.

Abstract

The extracellular matrix (ECM) is critical in regulating cell behavior and tissue function. This recognition has driven the development of ECM surrogates to better understand cell–ECM interactions and advance biomedical...

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Sui et al. (2025) studied this question.

synapsesocial.com/papers/68af541fad7bf08b1eadba5e https://doi.org/10.1039/d5bm00210a

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Revisiting the biophysical aspects of extracellular-matrix–mimicking hydrogels: what cells see vs. what cells feel

Key Points

Abstract

Discussion

Cite This Study

Revisiting the biophysical aspects of extracellular-matrix–mimicking hydrogels: what cells see vs. what cells feel

Key Points

Abstract

Discussion

Cite This Study

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