Molecular mimics of insulin/IGF facilitate viral pathogenesis in fish

Helena Safavi-­Hemami

doi:10.1016/j.celrep.2025.116138

August 1, 2025Cell ReportsOpen Access

Molecular mimics of insulin/IGF facilitate viral pathogenesis in fish

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Key Points

Viral mimicry of insulin and IGF enhances fish pathogenesis during infection, evading host defenses.
Key evidence indicates that these mimics play a significant role in viral manipulation of host signaling pathways.
Assessment of viral behavior and host interactions reveals critical insights into infection mechanisms in fish hosts.
Understanding viral mimicry in Iridoviridae could lead to improved disease management strategies in aquaculture.

Implication

The research demonstrates viral mimicry of insulin/IGF impacts pathogenesis in fish, highlighting infection mechanisms.

Abstract

Some Iridoviridae viruses manipulate host signaling through molecular mimicry of insulin/IGF-like peptides. Chuard et al.1 now elucidate the biological role of these viral mimics during infection in fish hosts.

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Cite This Study

Helena Safavi-Hemami (2025) studied this question.

synapsesocial.com/papers/68af55d1ad7bf08b1eadc606 https://doi.org/10.1016/j.celrep.2025.116138

View Full Paper

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Molecular mimics of insulin/IGF facilitate viral pathogenesis in fish

Key Points

Implication

Abstract

Discussion

Cite This Study

Molecular mimics of insulin/IGF facilitate viral pathogenesis in fish

Key Points

Implication

Abstract

Discussion

Cite This Study

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