Percutaneous Thermal Ablation for Early-Stage Breast Cancer: An Open-Label, Randomized, Phase II Trial to Select the Preferred Technique for Evaluating Thermal Ablation as a Surgical Alternative

Sophie M Wooldrik; Elles M.F. van de Voort; Gerson M. Struik; Belinda J. Schouten; Glenn Yo; Maura Macco; Frank Hulsebosch; Adriaan Moelker; Suzanne Wilhelmus; Renata Sinke; Erwin Birnie; Thijs van Dalen; Cornelis Verhoef; T.M.A.L. Klem

doi:10.1148/radiol.243386

August 1, 2025Radiology

Percutaneous Thermal Ablation for Early-Stage Breast Cancer: An Open-Label, Randomized, Phase II Trial to Select the Preferred Technique for Evaluating Thermal Ablation as a Surgical Alternative

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Key Points

Cryoablation achieved the highest complete ablation rate in early-stage breast cancer cases, with no reported complications.
The study recorded a complete ablation response for cryoablation, maximizing safety and efficacy for patients.
This phase II trial included three techniques: radiofrequency ablation, microwave ablation, and cryoablation, assessing their effectiveness.
Results indicate that cryoablation may be a suitable option for a subsequent phase III trial for better treatment outcomes.

Implication

Compares cryoablation, microwave, and radiofrequency ablation, suggesting cryoablation as a promising surgical alternative.

Abstract

This phase II study compared radiofrequency ablation, microwave ablation, and cryoablation for early-stage breast cancer, demonstrating that cryoablation achieved the highest complete ablation rate with no complications, supporting its selection for a phase III trial.

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Cite This Study

Wooldrik et al. (2025) studied this question.

synapsesocial.com/papers/68af55d8ad7bf08b1eadc980 https://doi.org/10.1148/radiol.243386

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Percutaneous Thermal Ablation for Early-Stage Breast Cancer: An Open-Label, Randomized, Phase II Trial to Select the Preferred Technique for Evaluating Thermal Ablation as a Surgical Alternative

Key Points

Implication

Abstract

Discussion

Cite This Study

Percutaneous Thermal Ablation for Early-Stage Breast Cancer: An Open-Label, Randomized, Phase II Trial to Select the Preferred Technique for Evaluating Thermal Ablation as a Surgical Alternative

Key Points

Implication

Abstract

Discussion

Cite This Study

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