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August 15, 2025Open Access

Supplementary Figure S3 from Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma

Ilango Balakrishnan Krishna Madhavan Angela Pierce Joshua Michlin Breauna Brunt Senthilnath Lakshmanachetty Dong Wang John DeSisto Zachary James Nuss Nathan Davidson Faye Walker Ammu Suresh Andrew M. Donson Bridget Sanford Kenneth L. Jones Etienne Danis Siddhartha S. Mitra Adam L. Green Nathan Dahl Rajeev Vibhakar Sujatha Venkataraman

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Key Points

CD99 depletion leads to significant tumor growth inhibition in diffuse midline glioma, enhancing therapeutic strategies.
Flow cytometry and western blotting confirmed CD99 depletion, showing effective targeting of DMG cells' growth pathways.
Aldefluor assays demonstrated altered stemness features in CD99-depleted glioma cells, indicating differentiation potential changes.
In vivo experiments showed notable apoptotic marker increases, calling for further exploration in clinical settings.

Implication

Observational analysis reveals that anti-CD99 antibody inhibits tumor growth in diffuse midline glioma, suggesting potential for targeted therapy.

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Cite This Study

Balakrishnan et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1c3 https://doi.org/10.1158/0008-5472.29918861

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma2025
2Supplementary Figure S5 from Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma2025
3Supplementary Figure S9 from Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma2025
4Supplementary FIgure S4 from Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma2025
5Supplementary Figure S1 from Development of an Anti-CD99 Antibody Enables Targeting of Diffuse Midline Glioma2025

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