Alleviating back pain in pregnancy: The role of collagen supplementation

Background: Lower back pain (LBP) is a common and disabling complaint during pregnancy, particularly in the second and third trimesters. Changes in biomechanics, hormones, and neuromuscular function contribute to the development of LBP. Collagen, a major component of connective tissue, plays a crucial role in maintaining tissue integrity and may help alleviate musculoskeletal pain. Material and Methods: This review aims to evaluate the potential role of collagen supplementation in reducing lower back pain in pregnant women by summarizing current biochemical and clinical evidence. A comprehensive literature search was conducted to identify peer-reviewed articles published in English or Polish that investigated collagen supplementation or its physiological effects related to musculoskeletal health, especially in pregnancy. Non-human studies, case reports, and editorials were excluded. Relevant full texts were reviewed for data on collagen’s mechanism of action, safety, and clinical outcomes in pregnant populations. Results: Hydrolyzed collagen peptides exhibit high bioavailability and promote fibroblast activity, extracellular matrix synthesis, and modulation of inflammatory pathways. These effects support tissue repair and joint stability, which are critical during pregnancy-related biomechanical stress. Although evidence from direct clinical trials on pregnant women is limited, studies in other populations suggest collagen supplementation may reduce musculoskeletal pain and improve function. No significant safety concerns have been reported. Conclusion: Collagen supplementation appears to be a promising adjunctive strategy for managing pregnancy-related lower back pain. However, well-designed clinical trials are needed to confirm its efficacy and safety in pregnant women.