A relação entre migrânea e a doença de Alzheimer

Introduction. Alzheimer's Disease (AD) is a progressive, multifactorial neurocognitive disorder characterized by the most frequent cause of dementia. Prevalent in the elderly, it affects cortical regions essential to memory, interfering with patients' autonomy and quality of life. Recent studies have suggested a relationship between this dementia disorder and migraine, one of the most common neurological conditions worldwide. Objectives. To identify the relationship between migraine and the development of AD, analyzing genetic studies, demographic spectra, and the influence or otherwise of migraine types. Method. This study is a systematic review based on articles published between 2019 and 2024, following the PRISMA methodology. Six studies were analyzed, focusing on patients with AD and/or migraine. The search used the descriptors "Alzheimer Disease" and "Migraine Disorders". Results. Despite the agreement of most articles regarding the association between migraine and Alzheimer's, elements such as methodological flaws and misfortunes in data collection prevent the establishment of this theme. However, genetic parameters, such as chromosomes 1 and 19, and the presenilin-1 gene, were ratified as coefficients in the equation between AD and migraine. Regarding the influence of the type of migraine on the onset of Alzheimer's disease, it was observed that only the subtype without aura has a causal relationship with dementia. Conclusion. Migraine can be considered a risk factor for the development of AD. Therefore, it is vital to conduct new studies, with rigorous methodological load and minimal limitations, to clarify this association and its mechanisms.