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This is a In Vitro Study study.

August 22, 2025Chemistry & Biodiversity

Molecular Docking and In Vitro Assessment of Gymnema sylvestre R. Br. and Trigonella foenum‐graecum L. Phytochemicals as Dual α‐Amylase and α‐Glucosidase Inhibitors

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Authors

SKSugandhi KatipearachchiLincoln University College MFMishal FaizanUniversity of Colombo PKPabasara KalansuriyaUniversity of Ruhuna

Discussion

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Overview

Molecular docking analysis reveals α-amylase and α-glucosidase inhibition in Gymnema sylvestre and Trigonella foenum-graecum extracts, indicating potential antidiabetic applications.

Key Points

In vitro testing disclosed T. foenum-graecum seed extract as a strong α-amylase inhibitor at 12.09 mg/mL, and α-glucosidase inhibition at 5.23 mg/mL.
Molecular docking simulations indicated stable binding interactions of trigoneoside XIIa and gymnemasaponin V with target proteins α-amylase and α-glucosidase, demonstrating their potential as drug candidates.
Virtual screening utilized a 221-compound library derived from G. sylvestre and T. foenum-graecum to assess phytochemical binding, supported by bioinformatics tools.
Findings highlight the importance of these phytochemicals in drug development, emphasizing a need for further clinical evaluation.

Cite This Study

Katipearachchi et al. (2025) studied this question.

synapsesocial.com/papers/68af59d2ad7bf08b1eade106 https://doi.org/10.1002/cbdv.202501525

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August 22, 2025Chemistry & Biodiversity

Molecular Docking and In Vitro Assessment of Gymnema sylvestre R. Br. and Trigonella foenum‐graecum L. Phytochemicals as Dual α‐Amylase and α‐Glucosidase Inhibitors

View Full Paper

Ask AI

Bookmark

Authors

SKSugandhi KatipearachchiLincoln University College MFMishal FaizanUniversity of Colombo PKPabasara KalansuriyaUniversity of Ruhuna

Discussion

Member takes

Overview

Molecular docking analysis reveals α-amylase and α-glucosidase inhibition in Gymnema sylvestre and Trigonella foenum-graecum extracts, indicating potential antidiabetic applications.

Key Points

In vitro testing disclosed T. foenum-graecum seed extract as a strong α-amylase inhibitor at 12.09 mg/mL, and α-glucosidase inhibition at 5.23 mg/mL.
Molecular docking simulations indicated stable binding interactions of trigoneoside XIIa and gymnemasaponin V with target proteins α-amylase and α-glucosidase, demonstrating their potential as drug candidates.
Virtual screening utilized a 221-compound library derived from G. sylvestre and T. foenum-graecum to assess phytochemical binding, supported by bioinformatics tools.
Findings highlight the importance of these phytochemicals in drug development, emphasizing a need for further clinical evaluation.

Cite This Study

Katipearachchi et al. (2025) studied this question.

synapsesocial.com/papers/68af59d2ad7bf08b1eade106 https://doi.org/10.1002/cbdv.202501525

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